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COMPOSITIONS CONTAINING PI3K INHIBITOR AND MEK INHIBITOR, AND ALSO THEIR APPLICATION FOR TREATMENT OF CANCER
专利权人:
МЕРК ПАТЕНТ ГМБХ (DE);САНОФИ (FR)
发明人:
ДЕБЮСШ Лоран (FR),ГАРСИЯ-ЭСЧЕВЕРРИЯ Карлос (FR),МА Цзяньго (DE),МАКМИЛЛАН Стюарт (DE),ОГДЕН Дженет Энн Мойрер (DE),ВЕНСАН Луак (FR)
申请号:
RU2013131241/15
公开号:
RU2013131241A
申请日:
2011.12.08
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. A composition comprising a compound of the following structural formula: or a pharmaceutically acceptable salt thereof, and a compound having a structural formula selected from the group consisting of or a pharmaceutically acceptable salt thereof. The composition of claim 1, further comprising a pharmaceutically acceptable carrier. The composition of claim 1, wherein said compound corresponding to formula (1) and said compound corresponding to formula (2a) or (2b) are present in amounts providing a synergistic effect associated with a reduction in tumor volume in a patient after administration of said composition .four. A method of treating a patient suffering from cancer, comprising administering to said patient a therapeutically effective amount of a compound of formula (1), or a pharmaceutically acceptable salt thereof, in combination with a compound of formula (2a) or formula (2b), or a pharmaceutically acceptable salt thereof. . The method according to claim 4, where an effective amount allows to achieve a synergistic effect associated with a decrease in tumor volume in the specified patient. The method according to claim 4, wherein the effective amount makes it possible to achieve stasis of the tumor in said patient. The method of claim 4, wherein said cancer is selected from the group consisting of non-small cell lung cancer, breast cancer, pancreatic cancer, liver cancer, prostate cancer, bladder cancer, cervical cancer, thyroid cancer, colorectal and direct cancer colon, liver cancer, muscle cancer, malignant blood diseases, melanoma, endometrial cancer and pancreatic cancer. 8. The method according to claim 4, where the cancer is selected from the group including colorectal cancer, endometrial cancer, malignant1. Композиция, содержащая соединение следующей структурной формулы:или его фармацевтически приемлемую соль, и соединение, имеющее структурную формулу, выбранную из группы, включающей в себяиили его фармацевтически приемлемую соль.2. Композиция по
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