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HLA G-MODIFIED CELLS AND METHODS
专利权人:
AgeX Therapeutics; Inc.
发明人:
Basil M. HANTASH
申请号:
US16659918
公开号:
US20200041512A1
申请日:
2019.10.22
申请国别(地区):
US
年份:
2020
代理人:
摘要:
Disclosed herein are methods for producing genetically modified cells expressing HLA-G (e.g., cell surface HLA-G) persistently, and nucleic acid compositions useful for generating such genetically modified cells. Also disclosed are cell therapy methods that utilize genetically modified cells that express HLA-G persistently. The HLA-G genetic modifications described herein provide the cells with characteristics of reduced immunogenicity and/or improved immunosuppression, such that these cells have the promise of being universal or improved donor cells for transplants, cellular and tissue regeneration or reconstruction, and other therapies.
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