The present invention relates to a combination of effective substances causing synergistic effects of multiple targeting, and to uses thereof. More particularly, the present invention relates to a composition for a functional health food； to a cosmetic composition； to a pain alleviating composition； and to a composition for treating/preventing itching or atopic dermatitis, wherein each composition contains, as active ingredients, two or more substances selected from a group consisting of (a) an antagonist to a 5-HT2(5-hydroxtryptamine subtype 2) receptor； (b) an antagonist to a P2X receptor； and (c) any one of an agonist to a glycine receptor, an antagonist to a glycine transporter (GlyT), an agonist to a gamma-aminobutyric acid (GABA) receptor, and an antagonist to GABA transporter 1 (GABA1). The multi-targeting complex composition (specifically, natural product complex composition) has synergistic effects, and thus a treatment using a combination of individual substances may achieve increased biological effects from the mechanisms which the individual substances involve. Thus, the multi-targeting complex composition may not only remarkably alleviate pain but may also increase effects of: alleviating symptoms of skin diseases such as itching and atopic dermatitis； preventing or ameliorating depression； relaxation； skin pore reduction； ameliorating wrinkles； skin regeneration； skin health； skin condition recovery； whitening； preventing or ameliorating athlete's foot； scalp health recovery and regeneration； stimulation of hair growth； prevention of premature gray hair； improving teeth or ameliorating periodontal diseases； etc.La présente invention concerne une combinaison de substances efficaces qui provoque des effets synergiques d'un ciblage multiple, et ses utilisations. Plus particulièrement, la présente invention concerne une composition pour un produit diététique fonctionnel ； pour une composition cosmétique ； pour une composition soulageant la douleur et pour
