The present invention provides methods for treating cancer using modulators of retinoid X receptor gamma (RXRG). The ability of RXRG antagonists to disrupt the association of complexes comprising RXRG is demonstrated. In certain embodiments, the invention provides methods of inhibiting proliferation of cancer cells with a compound described herein. In some embodiments, a compound used in accordance with the provided method is a retinoid X receptor gamma (RXRG) antagonist. In certain embodiments, the invention provides methods of inhibiting proliferation of cancer cells with KRAS, EGFR, or PTEN mutations with a RXRG antagonist.La présente invention concerne des procédés de traitement du cancer utilisant des modulateurs des récepteurs gamma des rétinoïdes X (RXRG). La capacité des antagonistes des RXRG à rompre lassociation des complexes comprenant les RXRG est démontrée ici.
