CHEN CHRISTINE HIU-TUNG,CHEN ZHUOLIANG,DORE MICHAEL,FORTANET JORGE GARCIA,KARKI RAJESH,KATO MITSUNORI,LAMARCHE MATTHEW J,PEREZ LAWRENCE BLAS,SMITH TROY DOUGLAS,WILLIAMS SARAH,GIRALDES JOHN WILLIAM,TOU
申请号:
AP2016009299
公开号:
AP2016009299A0
申请日:
2015.01.16
申请国别(地区):
AP
年份:
2016
代理人:
摘要:
in which p, q, Y1, Y2, R1, R2a, R2b, R3a, R3b, R4a, R4b, R5a, R5b, R7 and R8 are defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.