This creation discloses a kind of device of monitoring of physiologic state,The device system includes: a signal capturing unit,It is to the one first standard state pulse wave data for capturing the privileged site of organism and one first reactive hyperemia state pulse wave data; One adds pressure release unit,It is to the privileged site pressurization and pressure release to organism; One central processing unit,System with signal capturing unit and add pressure release unit electric property coupling,The first standard state pulse wave data can be converted into one second standard state pulse wave data with a unstable state non-linear transfer function and the first reactive hyperemia state pulse wave data is converted into one second reactive hyperemia state pulse wave data,And an endothelial function coefficient for organism is determined according to the second standard state pulse wave data and the second reactive hyperemia state pulse wave data,To analyze the physiological status of organism.本創作揭露一種監控生理狀態之裝置,該裝置係包含:一訊號擷取單元,係用以擷取生物體之特定部位的一第一標準狀態脈波資料與一第一反應性充血狀態脈波資料;一加洩壓單元,係用以對生物體之特定部位加壓與洩壓;一中央處理單元,係與訊號擷取單元以及加洩壓單元電性耦接,可運用一非穩態非線性轉換函數將第一標準狀態脈波資料轉換為一第二標準狀態脈波資料以及將第一反應性充血狀態脈波資料轉換為一第二反應性充血狀態脈波資料,並根據第二標準狀態脈波資料與第二反應性充血狀態脈波資料決定生物體的一內皮功能係數,以分析生物體之生理狀態。