HSU, MIN CHUAN,徐敏铨,徐敏銓,CHENG, YU KAO,郑玉杲,鄭玉杲,LIN, LI CHIN,林丽卿,林麗卿
申请号：
TW097102410
公开号：
TWI391150B
申请日:
2008.01.22
申请国别(地区):
TW
年份:
2013
代理人:
摘要：
An enteric sustained-release coated core includes a drug-containing core and a coating film. The coating film includes 20%~80% by weight of a hydrophobic polymer and 10%~70% by weight of an enterosoluble material. The dissolution rate of the medical component in the drug-containing core is approximately less than 10% in hydrochloric acid solution of pH 1~3 after 2 hours. The dissolution of the medical component in the drug-containing core sustains more than 5 hours in phosphate buffer solution of pH 5~8.一種腸溶性長效塗覆芯,包括一含藥核芯以及包覆含藥核芯之一膜衣層。膜衣層包括一疏水性高分子及一腸溶性物質。疏水性高分子佔膜衣層之重量比例約為20%~80%,腸溶性物質佔膜衣層之重量比例約為10%~70%。在酸鹼值大約1~3之鹽酸水溶液中,含藥核芯中的藥物於2小時後之溶出率不高於約10%。在酸鹼值大約5~8之磷酸鹽緩衝溶液中,含藥核芯中的藥物至少可持續溶出約5小時。
