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Compounds and compositions as protein kinase inhibitors
专利权人:
NOVARTIS AG
发明人:
COSTALES, ABRAN Q.,HUANG, SHENLIN,JIN, JEFF (XIANMING),LIU, ZUOSHENG,PECCHI, SABINA,POON, DANIEL,TELLEW, JOHN,ZHANG, QIONG
申请号:
ES10745280
公开号:
ES2527176T3
申请日:
2010.08.26
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
A compound of the formula I ** Formula ** wherein R1 is (i) (C1-C3) alkyl optionally substituted with cyano, -C (O) NH2, or hydroxy, or (ii) -X1NHC (O) OR1a, where X1 is (C1-C4) alkylene optionally substituted with 1 to 3 groups, each independently selected from halo, (C1-C4) alkyl, or halogen-substituted (C1-C4) alkyl and R1a is H, (C1 -C4), or (C1-C4) alkyl substituted with halogen; R2 is H or halogen; R3 is H, halogen, (C1-C4) alkoxy, (C1-C4) alkyl, halogen-substituted (C1-C4) alkoxy, or halogen-substituted (C1-C4) alkyl; R4 is halogen, H, or (C1-C4) alkyl; R5 is (C1-C6) alkyl, (C3-C6) cycloalkyl, branched (C3-C8) alkyl, halogen-substituted (C1-C6) alkyl, or halogen-substituted branched (C3-C8) alkyl; R6 is H, (C1-C4) alkyl, or halogen; and R7 is H, (C1-C6) alkyl, (C3-C6) cycloalkyl, (C3-C6) cycloalkyl, branched (C3-C8) alkyl, or phenyl, wherein said phenyl is optionally substituted with 1 to 3 substituents selected from halogen, (C1-C4) alkyl or (C1-C4) alkyl substituted with halogen; or a pharmaceutically acceptable salt thereof. wherein each cycloalkyl is saturated or partially unsaturated, monocyclic, fused bicyclic or bridged polycyclic.Un compuesto de la fórmula I**Fórmula** en donde R1 es (i) alquilo (C1-C3) opcionalmente sustituido con ciano, -C(O)NH2, o hidroxi, o (ii) -X1NHC(O)OR1a, donde X1 es alquileno (C1-C4) opcionalmente sustituido con 1 a 3 grupos, seleccionado cada uno independientemente de entre halo, alquilo (C1-C4), o alquilo (C1-C4) sustituido con halógeno y R1a es H, alquilo (C1-C4), o alquilo (C1-C4) sustituido con halógeno; R2 es H o halógeno; R3 es H, halógeno, alcoxi (C1-C4), alquilo (C1-C4), alcoxi (C1-C4) sustituido con halógeno, o alquilo (C1-C4) sustituido con halógeno; R4 es halógeno, H, o alquilo (C1-C4); R5 es alquilo (C1-C6), cicloalquilo (C3-C6), alquilo (C3-C8) ramificado, alquilo (C1-C6) sustituido con halógeno, o alquilo (C3-C8) ramificado sustituido con halógeno; R6 es H, alquilo (C1-C4), o halógeno; y R7 es H, alquilo (C1-C
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