The disclosure relates to methods of enhancing beneficial oral bacteria and decreasing harmful oral bacteria comprising administering oral care compositions comprising a saccharide prebiotic, e.g., selected from D-turanose, D-melezitose, D-lactitol, myo-inositol, and N-acetyl-D-mannosamine； and oral care compositions for use in such methods. The disclosure also relates to methods of using prebiotic oral care compositions, methods of screening, and methods of manufacture.該揭示內容係關於增加有益口腔細菌及減少有害口腔細菌之方法，其包括投遞包含醣類益生元，例如，選自於D-松二糖、D-蜜三糖、D-乳糖醇、肌醇，及N-乙醯基-D-甘露胺糖之口腔保健組成物；及使用於此等方法中之口腔保健組成物。該揭示內容亦關於使用益生元口腔保健組成物之方法，篩選之方法，及製造之方法。
