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COMPOSITION FOR APPLICATION IN THERAPY OF LACTOSE INTOLERANCE OR THE CONDITION ARISING AS A RESULT OF LACTASE INSUFFICIENCY
专利权人:
ВИТАКЭА ГМБХ УНД КО. КГ (DE)
发明人:
ВИРОБНИК Даниэль Хэнри (DE),ВИРОБНИК Исаак Харри (DE)
申请号:
RU2012137786/15
公开号:
RU2012137786A
申请日:
2011.02.04
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. Composition for use in the treatment of lactose intolerance or conditions resulting from lactase deficiency, where this composition is a non-dairy solid dosage form containing: (a) lactase, stable and active in the pH range from 3 to 6; however, the term "stable" means that lactase (a) retains at least 30% of its activity after incubation for one hour at a temperature of 37 ° C with a pH in the range from 3 to 6; and (b) one or more lactase-producing and / or lactase-containing microorganisms selected from Lactobacillus delbrueckii ssp bulgaricus and Steptococcus thermophilus; in which lactase (a) is different from lactase derived from said one or more microorganisms (b); and in which one or more lactase-producing and / or lactase-containing microorganisms (b) are in a dried form. The composition for use according to claim 1, wherein the dosage form is different from an enteric coated capsule. The composition of claim 1, wherein the lactase-producing and / or lactase-containing organisms are not enteric coated. The composition for use according to any one of claims 1 to 3, in which lactase (a) has maximum activity at a pH in the range from 3 to 6.5. A composition for use according to any one of claims 1 to 4, wherein the lactase (a) is derived from microorganisms, and the composition is substantially free of microorganisms from which this lactase is derived. Compositions for use according to any one of claims 1 to 5, which contains both Lactobacillus delbrueckii ssp bulgaricus and Steptococcus thermophilus. 7. Composition for use according to any one of claims 1 to 6, in which the solid dosage form is selected from capsules, table�1. Композиция для применения в терапии непереносимости лактозы или состояний, возникающих в результате лактазной недостаточности, где эта композиция является немолочной твердой дозированной формой, содержащей:(a) лактазу, стабильную и активную в диапазоне значений pH от 3 до 6; при этом термин «стабильная» означает, что лактаза (a) сохр
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