Mayo Foundation for Medical Education and Research
发明人:
BRIMIJOIN, William S.,GAO, Yang,CHEN, Ping,GENG, Liyi
申请号：
EP15785281
公开号：
EP3137098A4
申请日:
2015.04.29
申请国别(地区):
EP
年份:
2017
代理人:
摘要：
This document provides butyrylcholinesterases having an enhanced ability to hydrolyze acyl ghrelin as well as nucleic acids encoding such butyrylcholinesterases. This document also provides methods and materials for treating obesity and/or aggression. For example, methods for administering a nucleic acid encoding a wild-type or mutant butyrylcholinesterase having the ability to hydrolyze acyl ghrelin to a mammal under conditions wherein the level of acyl ghrelin within the mammal is reduced, under conditions wherein the rate of body weight gain of the mammal is reduced, under conditions wherein the mammals level of aggression is reduced, and/or under conditions wherein the mammals rate of developing stress-induced tissue damage are provided.
