The present invention relates to anti-EPHRINB 2 antiboies and its application methods. The present invention provides anti-eph rinB2 antibody, the composition comprising these antibody and use the method for these antibody.本發明涉及抗EPHRINB2抗體及其使用方法。本發明提供了抗EphrinB2抗體、包含這些抗體的組合物及使用這些抗體的方法。