A multivalent DR5-Binding Molecules can comprise Binding Domain(s) of anti-DR5 antibodies, and particularly Binding Domain(s) of anti-human DR5 antibodies. The DR5-Binding Molecules include bivalent and tetravalent molecules having two, three or four DR5-Binding Domains each capable of binding human DR5. The multivalent DR5-Binding Molecules can comprise diabodies, and more particularly, diabodies that comprise a covalently bonded complex of two or more polypeptide chains. The multivalent DR5-Binding Molecules can comprise fragments of the anti-DR5 antibodies DR5 mAb 1 and/or DR5 mAb 2, and/or humanized and chimeric versions of such antibodies.一種多價DR5結合分子，其包括抗-DR5抗體的結合結構域，尤其是抗-人DR5抗體的結合結構域。DR5結合分子包括具有兩個、三個或四個DR5-結合結構域的二價和四價分子，每一個結合結構域均能結合人DR5。此多價DR5結合分子可包括雙抗體。此雙抗體包括兩條或多條多肽鏈的共價結合的複合物。此多價DR5結合分子亦可包括DR5 mAb 1和/或DR5 mAb 2之抗-DR5抗體的片段和/或此種抗體的人源化和嵌合形式。
