The present invention generally relates to skin-mountable devices. A device in accordance with the invention comprises a skin-mountable unit having a mounting surface comprising adhesive for adhering the unit to the skin of a subject, and a handling unit releasably attached to the skin-mountable unit. The handling unit comprises an interior space at least partially accommodating the skin-mountable unit and has an opening through which the skin-mountable unit can be moved when detached from the handling unit, the handling unit having a portion surrounding the opening. A seal member is releasably attached to the circumferential portion, providing a closed space for the skin-mountable unit. The device allows for easy handling. The user can grip the handling unit and handle the combined device during operation. The handling unit can be designed and optimized for ease of use during manipulation of the skin-mountable unit.
