Matthew BECKER;Adrian DEFANTE;Jinjun ZHOU;Ali DHINOJWALA
发明人:
Matthew BECKER,Jinjun ZHOU,Adrian DEFANTE,Ali DHINOJWALA
申请号：
US15328983
公开号：
US20170210852A1
申请日:
2015.07.21
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention is directed to a novel group of amino acid-based poly(ester urea)s (PEUs) for use in biodegradable adhesive and related methods for their making and use. These novel amino acid-based PEUs have a wide variation in mechanical properties and degradation behavior that can be tuned by varying the amino acids and polyols used to form the polyester monomers that form the PEUs. Importantly, these novel PEUs have been shown to be non-toxic in vitro and in vivo and may be suitable to a wide variety of biomedical and other uses. In some embodiments, the adhesive properties of these degradable amino acid-based poly(ester urea) adhesives has been further improved by the incorporation of controlled amounts of catechol functional groups into the side chains of the PEU via post-polymerization functionalization chemistry.
