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RASAGILINE MESYLATE TABLET COATED WITH A COMPOSISITON COMPRISING METHACRYLIC ACID - ETHYL ACRYLATE COPOLYMER AND TRIETHYL CITRATE
专利权人:
TEVA PHARMACEUTICAL INDUSTRIES LTD.
发明人:
SAFADI, MUHAMMAD,LICHT, DANNIT,COHEN, RACHEL
申请号:
NZ58602509
公开号:
NZ586025A
申请日:
2009.01.09
申请国别(地区):
NZ
年份:
2012
代理人:
摘要:
A tablet comprising: a core comprising rasagiline mesylate and at least one pharmaceutically acceptable excipient and an acid resistant pharmaceutically acceptable coating, wherein said acid resistant pharmaceutically acceptable coating comprises methacrylic acid - ethyl acrylate copolymer (1:1) and a plasticizer and in the coating, the ratio of methacrylic acid - ethyl acrylate copolymer (1:1) to plasticizer by weight is 5 to 1, wherein the plasticizer is triethyl citrate and wherein said tablet releases the following percentages of rasagiline mesylate when placed in a basket apparatus in 500 mL of buffered aqueous media at 37°C at 75 revolutions per minute for 60 minutes under the following pH conditions: a) 0% in 0.1 N HCl b) between 0 and 20% in a phosphate buffer solution with a pH of 6.0. And further the Use of the tablet of any one of the tablet in the manufacture of a medicament for treating a patient suffering from Parkinsons disease
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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