Technische Universität Graz;Karl-Franzens-Universität Graz
发明人:
申请号：
EP17167299.1
公开号：
EP3263559A1
申请日:
2014.01.21
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
The present invention provides a small molecule inhibitor for adipose triglyceride lipase (ATGL) with the molecule having IC50 concentrations in the submicromolar range. The inhibitor has the basic structureas disclosed herein and is a competitive inhibitor that does not affect the activity of other known acylglycerol hydrolases. The inhibitor is orally bioavailable and capable of inhibiting lipolysis in vivo, such that it is therefore capable of serving as lead structure for the identification of further inhibitors.
