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Nanoparticle for improving intestinal permeability and thereof production method
专利权人:
IUCF-HYU (INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY);한양대학교 산학협력단
发明人:
LEE, HYEON GYU,이현규,LEE, JI SOO,이지수,KIM, EUN SUH,김은서,SUH, JI WOON,서지운,JE, HYUN JEONG,제현정,LEE, HYEON GYUKR,LEE, JI SOOKR,KIM, EUN SUHKR,SUH, JI WOONKR,JE, HYUN JEONGKR
申请号:
KR1020160054296
公开号:
KR1020170124689A
申请日:
2016.05.02
申请国别(地区):
KR
年份:
2017
代理人:
摘要:
The present invention relates to intestinal permeable nanoparticles manufactured by mixing chitosan and dextran sulfate at a weight ratio of 1 : 0.2-1, and to a production method thereof. The chitosan/dextran sulfate nanoparticles manufactured by the present invention shows excellent enterocyte adsorption abilities and collects an object to be collected (target material) which has low solubility, is unstable and has low internal resorption rates such as coenzyme Q10, thereby significantly increasing absorption of the object to be collected to enterocyte and increasing internal resorption rates of the object to be collected.본 발명은 키토산 및 덱스트란 설페이트를 1 : 0.2 ~ 1 중량비로 혼합하여 제조된 것을 특징으로 하는 장 투과성 나노입자 및 그 제조방법에 관한 것으로, 다. 본 발명에 의해 제조된 키토산/덱스트란 설페이트 나노입자는 우수한 장 세포 흡착능을 발휘하는데, 코엔자임Q10과 같이 용해도가 낮고, 불안정하며 체내 흡수율이 낮은 포집대상물(목적물질)을 포집함으로써, 포집대상물질의 장 세포로의 흡수를 현저히 향상시켜, 이들 포집대상물질의 체내 흡수율을 증진시킬 수 있다.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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