The present invention provides a method for producing retinal pigment epithelial cells including the following steps: (1) a first step for culturing pluripotent stem cells for a period that does not exceed 30 days by using a medium containing at least one type of substance selected from a group consisting of FGF receptor inhibitors and MEK inhibitors； and (2) a second step for forming the retinal pigment epithelial cells by culturing the cells obtained in the first step by using a medium containing at least one type of substance selected from a group consisting of Rho-signaling-pathway inhibitors and apoptosis inhibitors. With said method, it is possible to produce the retinal pigment epithelial cells from pluripotent stem cells in a more efficient, simple manner.
