CANNIZZARO CARINA E.,CANNIZZARO Carina E.,GRAUPE MICHAEL,GRAUPE Michael,GUERRERO JUAN A.,GUERRERO Juan A.,LU YAFAN,LU Yafan,STRICKLEY ROBERT G.,STRICKLEY Robert G.,VENKATARAMANI CHANDRASEKAR,VENKATARA
申请号：
SI201230340
公开号：
SI2726460T1
申请日:
2012.06.29
申请国别(地区):
SI
年份:
2015
代理人:
摘要：
Disclosed are N-[4-(2-oxo-1,2-dihydro-pyridin-4-yl)-benzyl]-benzamide derivatives which are useful as human mitochondrial aldehyde dehydrogenase (ALDH-2) inhibitors for treating chemical dependency on dopamine-producing agents such as cocaine, opiates, amphetamines, nicotine and alcohol. Also disclosed are pharmaceutical compositions comprising a therapeutically effective amount of said compounds and methods of using the compounds in the treatment of addiction.
