CANNIZZARO, CARINA E.,GRAUPE, MICHAEL,GUERRERO, JUAN A.,LU, YAFAN,STRICKLEY, ROBERT G.,VENKATARAMANI, CHANDRASEKAR,ZABLOCKI, JEFF
申请号：
PL12735394
公开号：
PL2726460T3
申请日:
2012.06.29
申请国别(地区):
PL
年份:
2016
代理人:
摘要：
Disclosed are N-[4-(2-oxo-1,2-dihydro-pyridin-4-yl)-benzyl]-benzamide derivatives which are useful as human mitochondrial aldehyde dehydrogenase (ALDH-2) inhibitors for treating chemical dependency on dopamine-producing agents such as cocaine, opiates, amphetamines, nicotine and alcohol. Also disclosed are pharmaceutical compositions comprising a therapeutically effective amount of said compounds and methods of using the compounds in the treatment of addiction.
