Presented herein are methods for the treatment of oncological disorders by the co¬ administration of CoQ10 formulations and chemo therapeutic agents and/or surgery. The CoQ10 formulations may be at least one of intravenous topical or by inhalation. The chemo therapeutic agents may be at least one of antimetabolites or anthracyc lines. Co administration of the CoQ10 formulations may be prior to concurrent or substantially concurrent with intermittent with or subsequent to the administration of the chemotherapy.