LEGASSIE, JASON D.,SANCILIO, FREDERICK D.,THORSTEINSSON, THORSTEINN,INSKEEP, PHILIP B.,PERSICANER, PETER H. R.,SHADIACK, ANNETTE
申请号：
ARP170100831
公开号：
AR108074A1
申请日:
2017.04.03
申请国别(地区):
AR
年份:
2018
代理人:
摘要：
A Pharmaceutical composition capable of Forming Micelles after Exposure to gastric environment.The pharmaceutical composition is suitable for managing Steroid Hormones, and the combination of estradiol and progesterone in particular, a subject which has need of them.Claim 1: to provide a Pharmaceutical composition improved oral bioavailability and \/ or estradiol and progesterone, estradiol, progesterone, Pharmaceutical composition, comprising:A Polysorbate, and an oil, medium chainWhere the Oil medium chain comprises at least about 50 Weight percent of a Monoglyceride predominantly medium chain estradiol and progesterone both Solubilized POr complete. Claim 8: the pharmaceutical Composition of claim 1, further comprising a polyoxyethylene Hydrogenated Castor Oil.The pharmaceutical Composition of claim 9: claim 1, which also includes a Derivative of D - - tocopherol polyethylene glycol succinate.Claim 21: an oral Pharmaceutical Composition of estradiol and progesterone, completely Solubilized, estradiol, which includes:Progesterone and a Polysorbate in a Weight ratio of from about 2 to about 2: 1: 1 and an oil medium chain that comprises a mixture of mono - and di Glycerides, medium chainThe Oil medium chain contains no more than about 10 Weight percent of triglyceride.Claim 33: a Pharmaceutical composition to provide improved oral bioavailability and \/ or estradiol and progesterone, estradiol, progesterone, Pharmaceutical composition, comprising:A Polysorbate, and an oil, medium chainWhere the Oil medium chain comprises at least about 50 percent by weight of a First component of Oil and medium chain estradiol and progesterone both Solubilized by CComplete.Una composición farmacéutica capaz de formar micelas tras la exposición al entorno gástrico. La composición farmacéutica es apta para administrar hormonas esteroides, y la combinación de estradiol y en particular progesterona, a un sujeto que tiene la necesidad de ellas. Reivindicación 1: Una composición farmacéu
