The present invention relates to B-domain truncated Factor VIII molecules with a modified circulatory half life, said molecule being covalently conjugated with a hydrophilic polymer. The invention furthermore relates to methods for obtaining such molecules as well as use of such molecules.本發明係關於具有改良之循環半衰期之B結構域截短型因子VIII分子,該分子與親水性聚合物共價共軛。本發明進一步係關於獲得該等分子之方法以及該等分子之用途。