橋聯雜環化合物及使用方法农业专利-农业学术服务平台

发明人:: PROTTER, ANDREW ASHER,波特　安卓　爱雪尔,波特　安卓　愛雪爾,HUNG, DAVID T.,修　大卫Ｔ,修　大衛Ｔ,CHAKRAVARTY, SARVAJIT,恰克拉维提　萨尔维吉特,恰克拉維提　薩爾維吉特,JAIN, RAJENDRA PARASMAL,珍　瑞珍卓　派瑞斯麦尔,珍　瑞珍卓　派瑞斯麥爾,波特安卓爱雪尔,波特安卓愛雪爾,修大卫T,修大衛T,恰克拉维提萨尔维吉特,恰克拉維提薩爾維吉特,珍瑞珍卓派瑞斯麦尔,珍瑞珍卓派瑞斯麥爾

摘要：: This disclosure relates to new compounds that may be used to modulate a histamine receptor in an individual. Novel compounds are described, including new bridged heterocyclic [4,3-b]indole compounds. Pharmaceutical compositions are also provided. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.本案係關於可用以調節個體之組織胺受體之新穎化合物。所描述的新穎化合物包括新穎橋聯雜環[4,3-b]吲哚化合物。本案亦提供醫藥組合物，亦提供包含該等化合物之醫藥組合物，亦提供該等化合物在包括治療認知病症、精神病、神經傳遞素介導之病症及/或神經元病症之多種治療應用中的使用方法。