IMPERIAL CANCER RESEARCH TECHNOLOGY, LTD.;YALE UNIVERSITY
发明人:
ISH-HOROWICZ, DAVID,HENRIQUE, DOMINGOS M.P.,LEWIS, JULIAN H.,MYAT, ANNA M.,ARTAVANIS-TSAKONAS, SPYRIDON,MANN, ROBERT S.,GRAY, GRACE E.
申请号：
CA2214830
公开号：
CA2214830C
申请日:
1996.03.07
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
The present invention relates to nucleotide sequences of vertebrate Serrategenes, and amino acid sequences of their encoded proteins, as well asderivatives (e.g., fragments) and analogs thereof. In a specific embodiment,the Serrate protein is a human protein. The invention further relates tofragments (and derivatives and analogs thereof) of a vertebrate Serrate whichcomprise one or more domains of the Serrate protein, including but not limitedto the intracellular domain, extracellular domain, DSL domain, cysteine richdomain, transmembrane region, membrane-associated region, or one or more EGF-like repeats of a Serrate protein, or any combination of the foregoing.Antibodies to vertebrate Serrate, its derivatives and analogs, areadditionally provided. Methods of production of the vertebrate Serrateproteins, derivatives and analogs, e.g., by recombinant means, are alsoprovided. Therapeutic and diagnostic methods and pharmaceutical compositionsare provided.In specific examples, isolated Serrate genes, from chick, mouse,Xenopus and human, are provided.
