ZHUANG LINGHANG,LEFTHERIS KATERINA,XU ZHENRONG,TICE COLIN M.,HIMMERLSBACH FRANK,CLAREMON DAVID A.
申请号：
TN2011000031
公开号：
TN2011000031A1
申请日:
2011.01.25
申请国别(地区):
TN
年份:
2012
代理人:
摘要：
This invention relates to novel compounds of the Formula Ik, Im1, Im2, Im5, In1, In2, In5, Io1, Io2, Io5, Ip1, Ip3, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11β-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of Cortisol in a cell or the inhibition of the conversion of cortisone to cortisol in a cell.
