OBAD, SUSANNA,KAUPPINEN, SAKARI,ELMEN, JOACIM,LINDOW, MORTEN,HEIDENBLAD, MARKUS
申请号：
NZ58367708
公开号：
NZ583677A
申请日:
2008.10.03
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
An oligomer having a complementary sequence of 7-10 nucleotides to a microRNA target. The oligomer has at least 70 percent of the nucleotides selected from Locked Nucleic Acid (LNA) or 2' substituted nucleotide analogues, wherein at least 50% of the nucleotides are LNA and the oligomer has at least one phosphorothioate internucleoside linkage. The microRNA target can be hsa-miR-122. The oligomer can be used to treat hepatitis C virus infection or hypercholesterolemia.
