Provided herein are a pharmaceutical composition for the prevention or treatment of a cardiovascular disease accompanied by diabetes, and a composite preparation including the pharmaceutical composition. The pharmaceutical composition includes amlodipine or a pharmaceutically acceptable salt thereof, losartan or a pharmaceutically acceptable salt thereof, and rosuvastatin or a pharmaceutically acceptable salt thereof.本發明提供一種預防或治療伴有糖尿病的心血管疾病的藥物組成物以及一種包含所述藥物組成物的複合製劑。所述藥物組成物包含氨氯地平或其藥學上可接受的鹽、絡舒坦或其藥學上可接受的鹽以及瑞舒伐他汀或其藥學上可接受的鹽。