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Variable region sequences of IL-31 monoclonal antibodies and methods of use
专利权人:
ZYMOGENETICS; INC.
发明人:
Rene, Shirley,Siadak, Anthony W.,Bilsborough, Janine
申请号:
AU2007290145
公开号:
AU2007290145B2
申请日:
2007.09.04
申请国别(地区):
AU
年份:
2012
代理人:
摘要:
Novel compositions derived from antigen-binding sites of immunoglobulinshaving affinity for IL-31 are provided. The compositions exhibit immunologicalbinding properties of antibody molecules capable of binding specifically toa human IL-31. CDR regions derived from same or different immunoglobulin moietiesare provided. Also provided are single chain polypeptides wherein VH and VL domainsare attached. The sFv molecules can include ancillary polypeptide moietieswhich can be bioactive, or which provide a site of attachment for other usefulmoieties. The compositions are useful in specific binding assays, affinitypurification schemes, drug or toxin targeting, imaging, and genetic or immunologicaltherapeutics for inflammatory diseases. The invention thus provides novelpolypeptides, the DNAs encoding those polypeptides, expression cassettescomprising those DNAs, and methods of inducing the production of the polypeptides.The invention further provides the amino acid sequences of the variable regionsof the monoclonal antibodies and use of these monoclonal antibody or antibodyfragment in conjunction with an an human IgG4 Fc molecule.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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