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Tablets with improved dissolution
专利权人:
大日本住友製薬株式会社
发明人:
柳田 万希子,西井 宏行,中園 昌幸
申请号:
JP2009553422
公开号:
JP5401327B2
申请日:
2009.02.10
申请国别(地区):
JP
年份:
2014
代理人:
摘要:
The present invention provides a tablet having improved dissolution property, which comprises (+)-3-{1-[3-(trifluoromethoxy)benzyl]piperidin-4-yl}-4-phenyl-3,4-dihydro-2(1H)-quinazolinone or a pharmaceutically acceptable salt thereof as an active component, and a production method thereof. A film-coated tablet obtained by mixing granulated particles obtained by granulating a mixture containing (a) the aforementioned active component, (b) one or more kinds of fillers selected from lactose, D-mannitol, erythritol and crystalline cellulose, (c) a cellulose-based disintegrant and (d) a water-soluble binder with a later powder containing (e) one or more kinds of fillers selected from lactose, D-mannitol and crystalline cellulose and/or (f) a cellulose-based disintegrant, forming the mixture, and applying film coating. A production method of a film-coated tablet, including a step of producing the granulated particles, a step of producing a tablet by mixing with the later powder and forming the mixture, and a step of applying a film coating to the obtained tablet.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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