Sara FRATTINI,Remko BAKKER,Riccardo GIOVANNINI,Dieter HAMPRECHT,Iain LINGARD,Alexander PAUTSCH,Bernd WELLENZOHN
申请号：
US15770762
公开号：
US20180305338A1
申请日:
2016.10.20
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention relates to compounds of general formula I, wherein D1 to D3, A, R1, R2, Y and n are defined as in claim 1, which have valuable pharmacological properties, in particular are inhibitors of plasma kallikrein. The compounds are suitable for treatment and prevention of diseases which can be influenced by influenced by inhibition of plasma kallikrein, such as diabetic complications, particularly in the treatment of retinal vascular permeability associated with diabetic retinopathy and diabetic macular edema.
