CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;UNIVERSITE D'ORLEANS
发明人:
Lucie PIGEON,Rachid, A. RAHMOUNI,Harivony, Chantal PICHON-RABENANDRASANA,Patrick MIDOUX
申请号：
US16495874
公开号：
US20200010866A1
申请日:
2018.03.21
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The application relates to the production of RNA of interest, more specifically of messenger RNA of interest or of long non-coding RNA of interest, by yeasts with recombinant pseudo-viral particles. The recombinant yeasts have been genetically modified in order to produce the RNA of interest in the form of a complex, particularly in the form of recombinant pseudo-viral particles. These recombinant pseudo-viral particles are produced from certain elements of yeast Ty retrotransposon, but do not retrotranscribe the RNA that they contain. Thus, the application relates to the components that are thus capable of being implemented or produced, and particularly to the nucleic acid constructs, kits, bacteria cells, yeast cells, culture or transfection media containing them, as well as to a method for producing a pharmaceutical composition, particularly for medical applications, more specifically for vaccines, anti-tumour and pro-regenerative applications.
