A system and method detects and provides alerts when a subject's physiological measurements indicate a likelihood of the presence of drug cravings and a possible return to drug use. The system includes a wearable sensor which monitors movement in three dimensions, Electro Dermal Response (EDR), and temperature. Initially, training measurements are taken while subject is under supervision and not taking drugs, and algorithms process the measurements to determine thresholds. After release from supervision, the physiological measurements are monitored, processed, and compared to the thresholds. When the comparison indicates a presence of cravings for drugs, an alert is provided to the subject and/or to monitoring personnel.