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Plasma cytochrome C as a biomarker for mitochondrial toxicity during antiretroviral therapy
专利权人:
发明人:
Elijah Paintsil,Allison Langs-Barlow
申请号:
US14725835
公开号:
US10012648B2
申请日:
2015.05.29
申请国别(地区):
US
年份:
2018
代理人:
摘要:
The present invention relates to the discovery that measurement of the level of cytochrome c (Cyt-C) in the plasma can be used as a diagnostic signature to predict antiretroviral therapy (ART) toxicity in human immunodeficiency virus (HIV) infected patients. Thus, in various embodiments described herein, the methods of the invention relate to methods of diagnosing a HIV patient with ART toxicity, methods of predicting a patients risk of having or developing toxicity for ART, methods of assessing if a patient will benefit from a change in the treatment strategies by adjusting the dosage and/or changing the medication or even terminating of ART, and methods of predicting antiretroviral drugs propensity for causing mitochondrial toxicity. Furthermore, the invention encompasses a diagnostic kit for carrying out the aforementioned methods.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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