System and operation method of acoustic-actuated optical coherence enhanced imaging lens are disclosed. The present invention relates to the optical coherent tomography (OCT) system that combines with focused ultrasound (FUS) by lens in order to enhance the contrast in optical imaging. In addition, the present disclosure uses a contract agent with microbubbles (MBs) to increase the effectiveness of the vivo diagnosis and the controlled drug release.聲致顯影增強光同調影像之鏡頭及其系統和運作方法,以鏡頭結合光學同調斷層掃描(Optical coherence tomography,OCT)和聚焦式超音波(Focused ultrasound,FUS),以加強光學影像對比,還可以利用微氣泡顯影劑,提升活體診斷及控制藥物釋放效果。100‧‧‧鏡頭10‧‧‧物鏡12‧‧‧前透鏡22‧‧‧壓電片24‧‧‧可透光薄片30‧‧‧容器31‧‧‧底部32‧‧‧裝載部34‧‧‧容置部36‧‧‧結合件38‧‧‧介質49‧‧‧光路50‧‧‧生物組織承載台
