Hyun Seok Kim;Min Ji Kim;Haeng Ran Kim;Ki Moon Park;Youngmin Lee;Kang Jin Cho
发明人:
Hyun Seok Kim,Ki Moon Park,Min Ji Kim,Youngmin Lee,Haeng Ran Kim,Kang Jin Cho
申请号：
US14389957
公开号：
US20150157675A1
申请日:
2012.04.02
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates to a Eupatorium spp. extract having anti-obesity effects as a result of decreasing adipocytes and increasing osteoblasts, as well as the effects of preventing bone disease or fractures by increasing osteoblasts and of preventing osteoporosis by decreasing adipocytes and increasing osteoblasts by the same proportion in mesenchymal stem cells. DCM fraction layers of a Eupatorium spp. stem extract collected on a monthly basis and Eupatorium spp. stem extract collected only in September may inhibit the activity of PPARγ, AP2, CD36, adiponectin C/EBPα, and LPL, which serve as significant factors for adipocyte differentiation in C3H10T1/2 cells and primary mesenchymal stem cells, which are pluripotent stem cell lines, and may increase the activity of ALP, osterix, CO1I and RUNX2, which serve as significant factors for osteoblast differentiation. The Eupatorium spp. extract of the present invention exhibits the effects of increasing bone mineral density (BMD) and decreasing adipocytes in bone marrow in an osteoporosis animal model experiment involving an ovariectomy, and therefore may be used as a useful material for preventing and treating osteoporosis.
