PROBLEM TO BE SOLVED: To provide compositions comprising deuterated (D) derivatives of ivacaftor, and pharmaceutically acceptable salts thereof, and methods of treating diseases and conditions that are beneficially treated by administering a CFTR (cystic fibrosis transmembrane conductance regulator) potentiator.SOLUTION: The present invention provides a composition comprising a compound of formula I, and pharmaceutically acceptable salt thereof (X1-X7 independently represent H or D Y1-Y6 independently represent CH3 or CD3 if all of Y1-Y6 is CH3, one or more of X1-X7 is D).SELECTED DRAWING: NoneCOPYRIGHT: (C)2017,JPO&INPIT【課題】イバカフトルの重水素(D)化誘導体及びその薬学的に許容される塩を含む組成物並びにCFTR(嚢胞性線維症膜コンダクタンス制御因子)増強物質を投与することにより有利に治療される疾患及び状態を治療する方法の提供。【解決手段】式Iの化合物を含む組成物。及びその薬学的に許容される塩。(X1~X7は各々独立にH又はD;Y1~Y6は各々独立にCH3又はCD3;Y1~Y6の全てがCH3の場合、X1~X7の一つ以上がD)【選択図】なし
