OBSCHESTVO S OGRANICHENNOI OTVETSTVENNOSTYU “NAUCHNOTEHNOLOGICHESKAYA FARMACEVTICHESKAYA FIRMA “POLYSAN”
发明人:
申请号：
ARP170102733
公开号：
AR109775A1
申请日:
2017.09.29
申请国别(地区):
AR
年份:
2019
代理人:
摘要：
Is related to the Chemical and Pharmaceutical Industry and, in particular,A method for producing a stabilized Pharmaceutical composition presented as an aqueous solution that can be used to obtain a intravenous drug containing SUCCINIC ACID,Nicotinamide, Riboflavin mononucleotide and Inosine as Active Ingredients and has cytoprotective Properties.A method for producing a stabilized Pharmaceutical composition known presented as an aqueous solution that would improve its safety in use through the application of sterilizationThermal.A method for producing a stabilized Pharmaceutical composition presented as an aqueous solution containing SUCCINIC ACID, Inosine, Nicotinamide,SODIUM Riboflavin mononucleotide as Active Ingredients, by the Dissolution of these in water with subsequent sterile Filtration, whereThe composition is supplemented with one or more pharmaceutically acceptable Components as the stabilizing Agent is selected from the Group comprising Sodium HydroxideTris (hydroxymethyl) aminomethane (TRIS), Ethanolamine, diethanolamine, Sodium carbonate, meglumine, until a stable solution with pH between 6.0 and 8.0, and the ratio of components,% by weightAs follows: @ @ @ @ @ @ @ @ @Se relaciona con la industria química y farmacéutica y, en particular, con un método para producir una composición farmacéutica estabilizada presentada como una solución acuosa que se puede usar para obtener un fármaco intravenoso que contiene ácido succínico, nicotinamida, inosina y riboflavina-mononucleótido como los ingredientes activos y que posee propiedades citoprotectoras. Un método para producir la composición farmacéutica conocida estabilizada presentada como una solución acuosa que permitiría mejorar su seguridad en el uso a través de la aplicación de esterilización térmica. Un método para producir una composición farmacéutica estabilizada presentada como una solución acuosa que contiene ácido succínico, inosina, nicotinamida, riboflavina-mononucleótido de sodio como ingredien
