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METHOD FOR PRODUCING A STABILIZED PHARMACEUTICAL COMPOSITION IN THE FROM OF AN AQUEOUS SOLUTION
专利权人:
OBSCHESTVO S OGRANICHENNOI OTVETSTVENNOSTYU "NAUCHNO-TEKHNOLOGICHESKAYA FARMACEVTICHESKAYA FIRMA "POLYSAN"
发明人:
KOVALENKO, Alexey Leonidovich,PETROV, Andrey Yurievich
申请号:
PH12019500702
公开号:
PH12019500702A1
申请日:
2019.03.29
申请国别(地区):
PH
年份:
2019
代理人:
摘要:
The invention relates to the chemical and pharmaceutical industry. A method for producing a stabilized pharmaceutical composition in the form of an aqueous solution comprising active ingredients which include succinic acid, inosine, nicotinamide and riboflavin mononucleotide sodium salt, wherein a stabilizing agent is further introduced into the composition as one or more pharmaceutically acceptable ingredients selected from the group consisting of sodium hydroxide, tris-(oxymethyl)aminomethane (TRIS), ethanolamine, diethanolamine, sodium carbonate and meglumine to obtain a stable aqueous solution having a pH value in the range of 6.0 to 8.0; the method further comprises a sterilizing filtration of the resulting dissolved composition, and an additional thermal sterilization at temperatures from 100øC and an exposure time of 8 minutes to 116øC and an exposure time of 2 minutes.
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