PROBLEM TO BE SOLVED: To provide physiologically acceptable compositions useful in a variety of medical and therapeutic applications.SOLUTION: The method of making compositions including one or plural embryonic proteins includes the steps of culturing cells on a surface in a suitable growth medium under hypoxic conditions, thereby producing soluble and non-soluble compositions including one or plural embryonic proteins.【課題】種々の医療的用途及び治療的用途において有用な生理学的に許容される組成物の提供。【解決手段】適した増殖培地における表面上にて低酸素条件の下で細胞を培養し、それによって1種又は複数種の胎児性タンパク質を含む可溶性組成物及び不溶性組成物を産生する段階を含む、1種又は複数種の胎児性タンパク質を含む組成物を作製する方法。【選択図】なし