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ON01910. NA ENHANCES CHEMOTHERAPEUTIC AGENT ACTIVITY IN DRUG-RESISTANT TUMORS
专利权人:
THE JOHNS HOPKINS UNIVERSITY
发明人:
JIMENO, ANTONIO,HIDALGO, MANUEL, MEDINA
申请号:
NZ58874908
公开号:
NZ588749A
申请日:
2008.04.17
申请国别(地区):
NZ
年份:
2012
代理人:
摘要:
Disclosed is a pharmaceutical composition comprising a mitotic disruptor/polo-like kinase (Plk) pathway inhibitor comprising ON01910, or a derivative thereof, and a nucleotide analog chemotherapeutic agent, wherein the derivative of ON01910 is a compound of the formula (1) as depicted herein,wherein the nucleotide analog chemotherapeutic agent is selected from the group consisting of purine and pyrimidine analogs which interfere with DNA synthesis, andwherein the composition includes a pharmaceutically and physiologically acceptable carrier, in an amount effective for use in a medicament, more preferably for preventing development of nucleotide analog chemotherapeutic agent resistance in a subject having cancer, and most preferably, for use as a medicament for treatment of nucleotide analog chemotherapeutic agent resistant cancer in a subject in need thereof.
来源网站:
中国工程科技知识中心
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