PENNING, Thomas D.,THOMAS, Sheela A.,HAJDUK, Philip J.,SAUER, Daryl R.,SARRIS, Kathy,GIRANDA, Vincent L.
申请号：
ES07784490
公开号：
ES2559679T3
申请日:
2007.06.20
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound of Formula (I) ** Formula ** or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3 and R4 are independently selected from the group consisting of hydrogen, alkenyl, alkoxy, alkoxycarbonyl, alkyl, alkynyl , cyano, haloalkoxy, haloalkyl, halogen, hydroxy, hydroxyalkyl, nitro, NRARB, and (NRARB) carbonyl； X is heterocycloalkyl, wherein X is unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents, Z, independently selected from the group consisting of alkyl, alkenyl, alkynyl, nitro, -CN, halogen, haloalkyl , alkoxy, alkylcarbonyl, alkylcarbonylalkyl, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, aryl, arylalkyl, arylalkoxy, arylalkoxycarbonyl, arylalkylcarbonyl, carboxy, carboxyalkyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkoxy, cycloalkylcarbonyl, heteroaryl, heteroarylalkyl, heteroarylcarbonyl, heteroarilcarbonilalquilo, heterocycle, heterocycloalkyl, heterocycloalkylcarbonyl, heterocyclocarbonyl , heterocyclocarbonylalkyl, hydroxy, hydroxyalkyl, NRCRD, (NRCRD) alkyl, (NRCRD) carbonyl, (NRCRD) carbonylalkyl, and oxo； wherein the aryl and heteroaryl moieties of Z are independently unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents selected from the group consisting of alkyl, formyl, halogen, and haloalkyl, and the heterocycle and cycloalkyl moieties of Z are independently unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents selected from the group consisting of alkyl, oxo, formyl, halogen, and haloalkyl； RC and RD are independently selected from the group consisting of hydrogen, alkyl, alkylcarbonyl, alquilcarboniloxialquilcarbonilo, arylcarbonyl, aryl, arylalkyl, arylalkylcarbonyl, carboxyalkyl, carboxyalkylcarbonyl, cycloalkyl, cycloalkylalkyl, haloalkyl, haloalkylcarbonyl, heteroaryl, heteroarylalkyl, heteroarylcarbonyl, heterocycle, heterocyclealkyl, heterocyclecarbonyl , heterocycloalkylcarbonyl, (NRARB) alkyl, and (NRARB) alkylcarbonyl； wherein if RC or RD are aryl, arylalkyl, arylalkylcarbonyl, arylcar
