Heinrich Haas,Sebastian Hörner,Isaac Hernan Esparza Borquez,Thomas Michael Hiller,Ferdia Bates
申请号：
US16757054
公开号：
US20200246267A1
申请日:
2018.10.18
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present disclosure relates to methods for preparing RNA lipoplex particles for delivery of RNA to target tissues after parenteral administration, in particular after intravenous administration, and compositions comprising such RNA lipoplex particles. The present disclosure also relates to methods which allow preparing RNA lipoplex particles in an industrial GMP-compliant manner. Furthermore, the present disclosure relates to methods and compositions for storing RNA lipoplex particles without substantial loss of the product quality and, in particular, without substantial loss of RNA activity.
