The disclosure relates to compounds and compositions for bone formation, fracture treatment, bone grafting, bone fusion, cartilage maintenance and repair, and methods related thereto. In certain embodiments, the disclosure relates to compositions comprising one or more compound(s) disclosed herein, such as 2-(2-Methoxybenzylidene)-1-indan-one； N-(4-arsonophenyl)glycine； 1,2-Benzenedicarboxylic acid, 1-(1-methylheptyl)ester； (4′-hydroxybiphenyl-4-yl) (phenyl)methanone； 2,2-dimethylchroman-6-carboxylic acid, (4,7-dihydroxy-8-methyl-2-oxo-2H-chromen-3-yl)amide； Ethyl 2-((4-chlorophenyl)thio)-1,3-benzothiazol-6-yl carbamate； Ethyl (2-(azepan-1-yl)benzo[d]thiazol-6-yl) carbamate； Porfiromycin； 1,3-benzodioxol-5-yl-[4-(3,4,5-trimethoxybenzoyl)-3-furyl]methanone； Tricinolone acetophenonide； 2,4-bis(3,4-dimethoxyphenyl)-4H-pyrano[3,2-c]chromen-5-one； Methyl 5-fluoro-4-methoxy-2,6-dioxohexahydro-5-pyrimidine carboxylate； 5-(naphthalen-1-yl)-1-phenyl-1h-tetrazole； 5-(2-phenylquinolin-4-yl)-1,3,4-oxadiazol-2-ol； N-[2,4,5-trimethyl-4-(trichloromethyl)cyclohexa-2,5-dien-1-ylidene]hydroxylamine； 4-benzoyl-3,4-dihydro-Benzo[f]quinoline-3-carbonitrile； 2-nitro-3-phenylspiro[cyclopropane-1,9′-fluorene]； 3-[4-(furan-2-ylmethyl)-5-sulfanylidene-1,2,4-dithiazolidin-3-ylidene]-1,1-dimethyl-thiourea； (6-acetamido-7-methyl-5,8-dioxo-2,3-dihydro-1H-pyrrolo[1,2-a]benzimidazol-3-yl)2-methoxyacetate； 5-Iodo-1H-indole-2,3-dione； 4,5-dihydro-1,2,9,10-tetramethoxy dibenzo[de,g]quinoline-6-carboxylic acid, ethyl ester； [2,6-bis(2,4-dimethylphenyl)-4-(2-methoxyacetyl)oxy-phenyl]2-methoxyacetate； 5,11-dimethyl-2-(2-piperidin-1-ylethyl)-6H-pyrido[4,3-b]carbazol-2-ium-9-ol； 2-[3-[[4-[(3-nitroacridin-9-yl)amino]phenyl]sulfamoyl]propyl]guanidine； 1-[[2-(dimethylamino)ethyl]amino]-7-hydroxy-4-methyl-9H-thioxanthen-9-one； 5-amino-1H-1,2,4-triazole-3-carboxylic acid, methyl ester； methyl N-cyano-N′-prop-2-en-1-ylcarbamimidothioate； 5,7-dinitro-8-quinolinol； 5-nitrosoquinolin-8-ol； Cantharidin； 1,7-Diamino
