Cary A. Kipke;Jerald K. Rasmussen;James I. Hembre;Peter D. Wickert
发明人:
Jerald K. Rasmussen,Cary A. Kipke,James I. Hembre,Peter D. Wickert
申请号：
US13258018
公开号：
US20120039920A1
申请日:
2010.03.19
申请国别(地区):
US
年份:
2012
代理人:
摘要：
A composition is disclosed comprising a hydrophobic monomer having the structure: CH2═CR4C(O)NHC(R1R1)(C(R1R1))nC(O)XR3 wherein n is an integer of 0 or 1； R1 is independently selected from at least one of: a hydrogen atom, alkyls aryls, and alkylaryls, wherein the alkyls, aryls, and alkylaryls have a total of 10 carbon atoms or less； R3 is a hydrophobic group selected from at least one of: alkyls, aryls, alkylaryls and ethers, wherein the alkyls, aryls, alkylaryls and ethers have a total number of carbon atoms ranging from 4 to 30； R4 H or CH3； X is O or NH. In some embodiments the hydrophobic monomer is derived from an amine or an alcohol (HXR3) that has a hydrophilicity index of 25 or less. A polymerizable composition comprising the hydrophobic monomer is disclosed, which optionally may comprise a cross-linking monomer and/or a non-cross-linking monomer. This polymerizable mixture may be used to from hydrophobically-derivatized supports, which may be used in applications such as hydrophobic interaction chromatography.
