A method of enhancing immune response is provided, including covalent linking an amphipathic peptide to an antigen to form an antigen-complex composition and administering the antigen-complex to a subject. In addition, a novel antigen-complex with amphipathic helical structure is provided as well, in which the ability of antigen delivery could be improved.本發明提供一種增進免疫反應的方法,其包含將兩親性螺旋胜肽共價接合至抗原以形成抗原複合體組合物;以及給予抗原複合體組合物予受試者。此外,本發明亦提供有著兩親性螺旋結構的新穎抗原複合物,其增進抗原遞送的能力。