The present invention provides a kind of method with disease condition relevant to PI3- kinases α and/or mTOR in what treatment subject. On the other hand, the present invention provides a kind of method with disease condition relevant to PI3- kinases α and/or mTOR in what treatment subject. It yet still another aspect, elaborating a kind of method for inhibiting the phosphorylation of both Akt (S473) and Akt (T308) in cell.本發明提供一種用於治療受試者中與PI3-激酶α和/或mTOR相關的疾病狀況的方法。另一方面,本發明提供一種用於治療受試者中與PI3-激酶α和/或mTOR相關的疾病狀況的方法。在又一方面,闡述了一種抑制細胞中Akt(S473)和Akt(T308)兩者的磷酸化的方法。