5-(2,4-DIHYDROXY-5-ISOPROPYL-PHENYL)-4-(4-MORPHOLIN-4-YLMETHYL-PHENYL)-ISOXAZOLE-3-CARBOXYLIC ACID ETHYLAMIDE MESYLATE, HYDRATES AND POLYMORPHS THEREOF, AND FORMULATIONS COMPRISING THESE FORMS
DRYSDALE MARTIN JAMES,DRYSDALE Martin James,DYMOCK BRIAN WILLIAM,DYMOCK Brian William,KRELL CHRISTOPH,KRELL Christoph,MUTZ MICHAEL,MUTZ Michael,PETERSEN HOLGER,PETERSEN Holger,ZHENG WEIJIA,ZHENG Weiji
申请号：
SI200830688
公开号：
SI2131845T1
申请日:
2008.02.28
申请国别(地区):
SI
年份:
2013
代理人:
摘要：
The present invention relates to new salt forms of 5-(2,4-dihydroxy-5-isopropyl-phenyl)-4-(4-morpholin-4-ylmethyl-phenyl)-isoxazole-3-carboxylic acid ethylamide, in particular the hydrochloride, tartrate, phosphate and hemi fumarate salt thereof to crystalline forms of such salts to polymorphs of 5-(2,4-dihydroxy-5-isopropyl-phenyl)-4-(4-morpholin-4-ylmethyl-phenyl)-isoxazole-3-carboxylic acid ethylamide to hydrates and polymorphs of the new salt forms mentioned above to the use of the new salt forms mentioned above for the manufacture of a medicament for the treatment of a disorder mediated by Hsp90 to a method for treating a disorder mediated by Hsp90 using the new salt forms to formulations comprising such salt forms, in particular aqueous solutions suitable for intravenous administration and to amber glass containers being filled with such formulations.
