Acid addition salts, hydrates and polymorphs of 5-(2,4-dihydroxy-5-isopropyl-phenyl)-4-(4-morpholin-4-ylmethyl-phenyl)-isoxazole-3-carboxylic acid ethylamide and formulations comprising these forms
Michael Mutz;Holger Petersen;Brian William Dymock;Martin James Drysdale;Christoph Krell;Weijia Zheng
发明人:
Martin James Drysdale,Brian William Dymock,Christoph Krell,Michael Mutz,Holger Petersen,Weijia Zheng
申请号：
US12529090
公开号：
US08163747B2
申请日:
2008.02.28
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to new salt forms of 5-(2,4-dihydroxy-5-isopropyl-phenyl)-4-(4-morpholin-4-ylmethyl-phenyl)-isoxazole-3-carboxylic acid ethylamide, in particular the mesylate, hydrochloride, tartrate, phosphate and hemi fumarate salt thereof； to crystalline forms of such salts； to polymorphs of 5-(2,4-dihydroxy-5-isopropyl-phenyl)-4-(4-morpholin-4-ylmethyl-phenyl)-isoxazole-3-carboxylic acid ethylamide； to hydrates and polymorphs of the new salt forms mentioned above； to the use of the new salt forms mentioned above for the manufacture of a medicament for the treatment of a disorder mediated by Hsp90； to a method for treating a disorder mediated by Hsp90 using the new salt forms； to formulations comprising such salt forms, in particular aqueous solutions suitable for intravenous administration； and to amber glass containers being filled with such formulations.
